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Category Archive for: ‘EPL Services’

  • Histology – How to Ensure the Quickest Possible Timeline

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    With the processing of up to 50,000 tissues per month, and projects regularly flowing in and out of our labs, histology scheduling at EPL is a continual process. Recognizing that the project timeline, in addition to quality and expertise, is one of the most important …

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  • EPL Pathology Peer Review

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    When selecting a Pathology Peer Review provider, experience is an important factor to consider in order to ensure high quality pathology data.  Over the last two years alone, EPL has conducted more than 250 pathology peer reviews.  These pathology peer reviews have been conducted internationally, …

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  • Get to Know Aclairo

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    Aclairo® Pharmaceutical Development Group, Inc. is committed to delivering independent and objective nonclinical and regulatory advice to the pharmaceutical industry. Every member of Aclairo’s staff strives to provide our clients with superior advice, analysis, work product and program assistance.  Aclairo’s unique experience and capabilities help our …

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  • EPL’s SEND Capabilities

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    The Standard for Exchange of Nonclinical Data (SEND) provides preclinical study data standards that will allow for a more consistent and streamlined review process by the US FDA.  In general, SEND formats apply to studies started after Dec. 17, 2016 for NDAs, BLAs, and ANDAs, …

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  • Rabbit Eye Half

    A Closer Look at Ocular Toxicity Studies

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    The eye and the ocular adnexa are common target organs in toxicology studies, but the appropriate evaluation of ocular tissues is a specialized endeavor.   Compared to routine toxicity studies, ocular toxicity studies require methodological modifications at almost every stage from study design to the final …

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  • Stereology

    Stereology: Turn Up the Volume!

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    Stereology is a tool for obtaining unbiased estimates of object numbers and/or sizes within three-dimensional regions of interest.  For biological samples, quantitative measurements are potentially more objective and accurate when compared to traditional semi-quantitative grading of findings by pathologists (i.e., scoring of morphologic changes as …

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  • DART

    EPL Necropsy Teams Capable of Providing Specialized DART Necropsies

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    We are pleased to announce that EPL’s necropsy teams have received specialized training in support of Developmental and Reproductive Toxicology (DART) necropsies.  Training in techniques used for DART studies was provided by Dr. Stephen Harris at Smithers Avanza Toxicology Services. DART training is focused primarily …

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  • Research and Development Pathology Support

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    EPL has extensive and diverse expertise and work experience in support of the pharmaceutical and biotechnology industries.  This includes supporting research from exploratory stages through submission of information to regulatory agencies and participating in follow-up actions to resolve questions arising from animal toxicity or efficacy studies. …

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  • Gamma-H2ZX Novel Biomarker for DNA Double-strand Breaks

    The Benefits of Immunohistochemistry (IHC)

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    Immunohistochemistry (IHC) has become a routinely used methodology for investigative and diagnostic evaluations that utilizes antigen-antibody reactions to identify antigens within cells or tissues.  While antigens are usually proteins, other antigenic biological products can also be recognized by antibodies including carbohydrates, lipids, nucleic acids, and …

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  • Retina

    Ocular Toxicity Studies: Specialized Necropsy, Histology, and Pathology Methods

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    The eye and the ocular adnexa are common target organs in toxicology studies, but the appropriate evaluation of ocular tissues is a specialized endeavor.  Compared to routine toxicity studies, ocular toxicity studies require methodological modifications at almost every stage from study design to the final …

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