EPL Participates in SETAC Pellston Workshop for Risk Assessment Approaches for Endocrine-Active Chemicals


Dr. Jeff Wolf, EPL CSO and Manager of Pathology at the Virginia Laboratory, participated in a SETAC-Pellston Workshop™ entitled “”Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Chemicals (EHRA): Developing Technical Guidance based on case studies to Support Decision Making.”  The workshop was held in Pensacola, FL from January 31-February 5, 2016.

The primary goal of the workshop was to provide objective recommendations, based on the current level of scientific understanding, to allow regulators/policy makers to make informed decisions on whether to select a hazard or a risk based regulatory approach for a given endocrine-disrupting chemical (EDC). The workshop additionally considered recent developments in the identification and testing of EDCs.  Participants included 49 international experts representing industry, government, and academia, and funding came from all three sectors.

As a basis for understanding various considerations of EDC hazard and risk assessment, case studies were conducted on six endocrine active substances that represented of a range of endocrine modes of action: ethinylestradiol, perchlorate, propiconazole, trenbolone, tributyltin and vinclozolin. This exercise involved the review of hundreds of published articles per chemical, which entailed both data reliability and weight of evidence assessments.  The workshop also highlighted areas of scientific uncertainty, and made specific recommendations for research and methods-development to resolve some of these issues.

On the first morning of the workshop, Dr. Wolf gave a 40-minute presentation entitled “Evaluating the Credibility of Histopathology Data in Environmental Endocrine Toxicity Studies”, during which he described the process and outcome associated with his review of 189 papers from the EDC case study literature to assess the reliability and plausibility of the published histopathologic findings.

The culmination of the workshop’s efforts will be six papers to be published in Environmental Toxicology and Chemistry and/or Integrated Environmental Assessment and Management.

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